The lipid kinase PIP5K1C regulates pain signaling and sensitization

Numerous pain-producing (pronociceptive) receptors signal via phosphatidylinositol 4,5- bisphosphate (PIP(2)) hydrolysis. However, it is currently unknown which lipid kinases generate PIP(2) in nociceptive dorsal root ganglia (DRG) neurons and if these kinases regulate pronociceptive receptor signal...

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Detalhes bibliográficos
Main Authors: Wright, Brittany D., Loo, Lipin, Street, Sarah E., Ma, Anqi, Taylor-Blake, Bonnie, Stashko, Michael A., Jin, Jian, Janzen, William P., Frye, Stephen V., Zylka, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074510/
https://ncbi.nlm.nih.gov/pubmed/24853942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.04.006
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