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Mutant TP53 Posttranslational Modifications: Challenges and Opportunities
The wild-type human p53 (TP53) tumor suppressor can be posttranslationally modified at over 60 of its 393 residues. These modifications contribute to changes in TP53 stability and in its activity as a transcription factor in response to a wide variety of intrinsic and extrinsic stresses in part thro...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4074372/ https://ncbi.nlm.nih.gov/pubmed/24395704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.22506 |
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