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Mutant TP53 Posttranslational Modifications: Challenges and Opportunities

The wild-type human p53 (TP53) tumor suppressor can be posttranslationally modified at over 60 of its 393 residues. These modifications contribute to changes in TP53 stability and in its activity as a transcription factor in response to a wide variety of intrinsic and extrinsic stresses in part thro...

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Detalhes bibliográficos
Main Authors: Nguyen, Thuy-Ai, Menendez, Daniel, Resnick, Michael A., Anderson, Carl W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074372/
https://ncbi.nlm.nih.gov/pubmed/24395704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.22506
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