Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1

BACKGROUND: Diabetic women are five times more likely to develop congestive heart failure compared with two fold for men. The underlying mechanism for this gender difference is not known. Here we investigate the molecular mechanisms responsible for this female disadvantage and attempt safeguarding c...

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Detalhes bibliográficos
Main Authors: Moore, Andrew, Shindikar, Amol, Fomison-Nurse, Ingrid, Riu, Federica, Munasinghe, Pujika E, Parshu Ram, Thrishila, Saxena, Pankaj, Coffey, Sean, Bunton, Richard W, Galvin, Ivor F, Williams, Michael JA, Emanueli, Costanza, Madeddu, Paolo, Katare, Rajesh
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073808/
https://ncbi.nlm.nih.gov/pubmed/24685144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-13-68
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