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Substrate Binding Pocket Residues of Human Alkyladenine-DNA Glycosylase Critical for Methylating Agent Survival
Human alkyladenine-DNA glycosylase (AAG) initiates base excision repair (BER) of alkylated and deaminated bases in DNA. Here, we assessed the mutability of the AAG substrate binding pocket, and the essentiality of individual binding pocket amino acids for survival of methylation damage. We used olig...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4073691/ https://ncbi.nlm.nih.gov/pubmed/18706524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2008.06.019 |
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