Substrate Binding Pocket Residues of Human Alkyladenine-DNA Glycosylase Critical for Methylating Agent Survival

Human alkyladenine-DNA glycosylase (AAG) initiates base excision repair (BER) of alkylated and deaminated bases in DNA. Here, we assessed the mutability of the AAG substrate binding pocket, and the essentiality of individual binding pocket amino acids for survival of methylation damage. We used olig...

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Bibliografski detalji
Glavni autori: Chen, Cheng-Yao, Guo, Haiwei H., Shah, Dharini, Blank, A., Samson, Leona D., Loeb, Lawrence A.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073691/
https://ncbi.nlm.nih.gov/pubmed/18706524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2008.06.019
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