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Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration
The processing of Amyloid Precursor Proteins (APPs) results in several fragments, including soluble N-terminal ectodomains (sAPPs) and C-terminal intracellular domains (AICD). sAPPs have been ascribed neurotrophic or neuroprotective functions in cell culture, although β-cleaved sAPPs can have delete...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4073673/ https://ncbi.nlm.nih.gov/pubmed/22266106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2011.12.047 |
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