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Structure-Based Design of Non-Natural Amino Acid Inhibitors of Amyloid Fibrillation
Many globular and natively disordered proteins can convert into amyloid fibers. These fibers are associated with numerous pathologies(1) as well as with normal cellular functions(2,3), and frequently form during protein denaturation(4,5). Inhibitors of pathological amyloid fibers could serve as lead...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4073670/ https://ncbi.nlm.nih.gov/pubmed/21677644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10154 |
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