Rational design of potent domain antibody inhibitors of amyloid fibril assembly

Antibodies hold significant potential for inhibiting toxic protein aggregation associated with conformational disorders such as Alzheimer’s and Huntington’s diseases. However, near-stoichiometric antibody concentrations are typically required to completely inhibit protein aggregation. We posited tha...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ladiwala, Ali Reza A., Bhattacharya, Moumita, Perchiacca, Joseph M., Cao, Ping, Raleigh, Daniel P., Abedini, Andisheh, Schmidt, Ann Marie, Varkey, Jobin, Langen, Ralf, Tessier, Peter M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2012
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523860/
https://ncbi.nlm.nih.gov/pubmed/23161913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208797109
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