Rational design of potent domain antibody inhibitors of amyloid fibril assembly

Antibodies hold significant potential for inhibiting toxic protein aggregation associated with conformational disorders such as Alzheimer’s and Huntington’s diseases. However, near-stoichiometric antibody concentrations are typically required to completely inhibit protein aggregation. We posited tha...

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Detalhes bibliográficos
Main Authors: Ladiwala, Ali Reza A., Bhattacharya, Moumita, Perchiacca, Joseph M., Cao, Ping, Raleigh, Daniel P., Abedini, Andisheh, Schmidt, Ann Marie, Varkey, Jobin, Langen, Ralf, Tessier, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523860/
https://ncbi.nlm.nih.gov/pubmed/23161913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208797109
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