Structure-Based Design of Non-Natural Amino Acid Inhibitors of Amyloid Fibrillation

Many globular and natively disordered proteins can convert into amyloid fibers. These fibers are associated with numerous pathologies(1) as well as with normal cellular functions(2,3), and frequently form during protein denaturation(4,5). Inhibitors of pathological amyloid fibers could serve as lead...

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Autors principals: Sievers, Stuart A., Karanicolas, John, Chang, Howard W., Zhao, Anni, Jiang, Lin, Zirafi, Onofrio, Stevens, Jason T., Münch, Jan, Baker, David, Eisenberg, David
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073670/
https://ncbi.nlm.nih.gov/pubmed/21677644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10154
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