Colon-Specific Deletion of Epithelial Sodium Channel Causes Sodium Loss and Aldosterone Resistance

Aldosterone promotes electrogenic sodium reabsorption through the amiloride-sensitive epithelial sodium channel (ENaC). Here, we investigated the importance of ENaC and its positive regulator channel-activating protease 1 (CAP1/Prss8) in colon. Mice lacking the αENaC subunit in colonic superficial c...

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Détails bibliographiques
Auteurs principaux: Malsure, Sumedha, Wang, Qing, Charles, Roch-Philippe, Sergi, Chloe, Perrier, Romain, Christensen, Birgitte Mønster, Maillard, Marc, Rossier, Bernard C., Hummler, Edith
Format: Artigo
Langue:Inglês
Publié: American Society of Nephrology 2014
Sujets:
Basic Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073440/
https://ncbi.nlm.nih.gov/pubmed/24480829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013090936
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