Nano-scale Liquid Chromatography/Mass Spectrometry and On-the-fly Orthogonal Array Optimization for Quantification of Therapeutic Monoclonal Antibodies and the Application in Preclinical Analysis

Therapeutic monoclonal antibodies (mAb) constitute a group of highly effective agents for treating various refractory diseases. Nonetheless it is challenging to achieve selective and accurate quantification of mAb in pharmaceutical matrices, which is required by PK studies. Liquid chromatography/mas...

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Bibliographische Detailangaben
Hauptverfasser: Duan, Xiaotao, Dai, Lipeng, Chen, Shang-Chiung, Balthasar, Joseph P., Qu, Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073258/
https://ncbi.nlm.nih.gov/pubmed/22770385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2012.06.007
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