Human IGF1 Regulates Midgut Oxidative Stress and Epithelial Homeostasis to Balance Lifespan and Plasmodium falciparum resistance in Anopheles stephensi

Insulin and insulin-like growth factor signaling (IIS) regulates cell death, repair, autophagy, and renewal in response to stress, damage, and pathogen challenge. Therefore, IIS is fundamental to lifespan and disease resistance. Previously, we showed that insulin-like growth factor 1 (IGF1) within a...

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Autores principales: Drexler, Anna L., Pietri, Jose E., Pakpour, Nazzy, Hauck, Eric, Wang, Bo, Glennon, Elizabeth K. K., Georgis, Martha, Riehle, Michael A., Luckhart, Shirley
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072789/
https://ncbi.nlm.nih.gov/pubmed/24968248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004231
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