Human IGF1 Regulates Midgut Oxidative Stress and Epithelial Homeostasis to Balance Lifespan and Plasmodium falciparum resistance in Anopheles stephensi

Insulin and insulin-like growth factor signaling (IIS) regulates cell death, repair, autophagy, and renewal in response to stress, damage, and pathogen challenge. Therefore, IIS is fundamental to lifespan and disease resistance. Previously, we showed that insulin-like growth factor 1 (IGF1) within a...

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Detalhes bibliográficos
Main Authors: Drexler, Anna L., Pietri, Jose E., Pakpour, Nazzy, Hauck, Eric, Wang, Bo, Glennon, Elizabeth K. K., Georgis, Martha, Riehle, Michael A., Luckhart, Shirley
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072789/
https://ncbi.nlm.nih.gov/pubmed/24968248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004231
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