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Overexpression of phosphatase and tensin homolog improves fitness and decreases Plasmodium falciparum development in Anopheles stephensi

The insulin/insulin-like growth factor signaling (IIS) cascade is highly conserved and regulates diverse physiological processes such as metabolism, lifespan, reproduction and immunity. Transgenic overexpression of Akt, a critical regulator of IIS, was previously shown to shorten mosquito lifespan a...

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Detalhes bibliográficos
Main Authors: Hauck, Eric S., Antonova-Koch, Yevgeniya, Drexler, Anna, Pietri, Jose, Pakpour, Nazzy, Liu, Darin, Blacutt, Jacob, Riehle, Michael A., Luckhart, Shirley
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788859/
https://ncbi.nlm.nih.gov/pubmed/23774695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.micinf.2013.05.006
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