Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia

Many human cancers are dramatically accelerated by chronic inflammation. However the specific cellular and molecular elements mediating this effect remain largely unknown. Using a murine model of pancreatic intraepithelial neoplasia (PanIN), we found that Kras(G12D) induces expression of functional...

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Autores principales: McAllister, Florencia, Bailey, Jennifer M., Alsina, Janivette, Nirschl, Christopher J., Sharma, Rajni, Fan, Hongni, Rattigan, Yanique, Roeser, Jeffrey C., Lankapalli, Rachana H., Zhang, Hao, Jaffee, Elizabeth M., Drake, Charles G., Housseau, Franck, Maitra, Anirban, Kolls, Jay K., Sears, Cynthia L., Pardoll, Drew M., Leach, Steven D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072043/
https://ncbi.nlm.nih.gov/pubmed/24823639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.03.014
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