Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia

Many human cancers are dramatically accelerated by chronic inflammation. However the specific cellular and molecular elements mediating this effect remain largely unknown. Using a murine model of pancreatic intraepithelial neoplasia (PanIN), we found that Kras(G12D) induces expression of functional...

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Detalhes bibliográficos
Main Authors: McAllister, Florencia, Bailey, Jennifer M., Alsina, Janivette, Nirschl, Christopher J., Sharma, Rajni, Fan, Hongni, Rattigan, Yanique, Roeser, Jeffrey C., Lankapalli, Rachana H., Zhang, Hao, Jaffee, Elizabeth M., Drake, Charles G., Housseau, Franck, Maitra, Anirban, Kolls, Jay K., Sears, Cynthia L., Pardoll, Drew M., Leach, Steven D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072043/
https://ncbi.nlm.nih.gov/pubmed/24823639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.03.014
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