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Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors

Choline kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described.

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Bibliographische Detailangaben
Hauptverfasser: Trousil, Sebastian, Carroll, Laurence, Kalusa, Andrew, Aberg, Ola, Kaliszczak, Maciej, Aboagye, Eric O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071626/
https://ncbi.nlm.nih.gov/pubmed/24976941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3MD00068K
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