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A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth
BACKGROUND: This study investigates whether a histone deacetylase subtype 6 (HDAC6) inhibitor could be used in the treatment of solid tumours. METHODS: We evaluated the effect of a novel inhibitor, C1A, on HDAC6 biochemical activity and cell growth. We further examined potential of early noninvasive...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3566806/ https://ncbi.nlm.nih.gov/pubmed/23322205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.576 |
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