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A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth

BACKGROUND: This study investigates whether a histone deacetylase subtype 6 (HDAC6) inhibitor could be used in the treatment of solid tumours. METHODS: We evaluated the effect of a novel inhibitor, C1A, on HDAC6 biochemical activity and cell growth. We further examined potential of early noninvasive...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kaliszczak, M, Trousil, S, Åberg, O, Perumal, M, Nguyen, Q-D, Aboagye, E O
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566806/
https://ncbi.nlm.nih.gov/pubmed/23322205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.576
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