Characterization of a new small-molecule inhibitor of HDAC6 in glioblastoma

Histone deacetylase 6 (HDAC6) is an epigenetic modifier that is an attractive pharmacological target in cancer. In this work, we show that HDAC6 is elevated in glioblastoma, the most malignant and common brain tumor in adults, in which its high levels correlate with poor patient survival and is more...

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Vydáno v:Cell Death Dis
Hlavní autoři: Auzmendi-Iriarte, Jaione, Saenz-Antoñanzas, Ander, Mikelez-Alonso, Idoia, Carrasco-Garcia, Estefania, Tellaetxe-Abete, Maitena, Lawrie, Charles H., Sampron, Nicolás, Cortajarena, Aitziber L., Matheu, Ander
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265429/
https://ncbi.nlm.nih.gov/pubmed/32488056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2586-x
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