The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth

The glycerophospholipid phosphatidylcholine is the most abundant phospholipid species of eukaryotic membranes and essential for structural integrity and signaling function of cell membranes required for cancer cell growth. Inhibition of choline kinase alpha (CHKA), the first committed step to phosph...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Trousil, Sebastian, Kaliszczak, Maciej, Schug, Zachary, Nguyen, Quang-De, Tomasi, Giampaolo, Favicchio, Rosy, Brickute, Diana, Fortt, Robin, Twyman, Frazer J., Carroll, Laurence, Kalusa, Andrew, Navaratnam, Naveenan, Adejumo, Thomas, Carling, David, Gottlieb, Eyal, Aboagye, Eric O.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095062/
https://ncbi.nlm.nih.gov/pubmed/27206796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9466
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