Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging

The number of newly formed neurons declines rapidly during aging, and this decrease in neurogenesis is associated with decreased function of neural stem/progenitor cells (NPCs). Here, we determined that a WIP1-dependent pathway regulates NPC differentiation and contributes to the age-associated decl...

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Bibliografiske detaljer
Main Authors: Zhu, Yunhua, Demidov, Oleg N., Goh, Amanda M., Virshup, David M., Lane, David P., Bulavin, Dmitry V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071391/
https://ncbi.nlm.nih.gov/pubmed/24911145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73015
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