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Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging

The number of newly formed neurons declines rapidly during aging, and this decrease in neurogenesis is associated with decreased function of neural stem/progenitor cells (NPCs). Here, we determined that a WIP1-dependent pathway regulates NPC differentiation and contributes to the age-associated decl...

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Detalhes bibliográficos
Main Authors: Zhu, Yunhua, Demidov, Oleg N., Goh, Amanda M., Virshup, David M., Lane, David P., Bulavin, Dmitry V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071391/
https://ncbi.nlm.nih.gov/pubmed/24911145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73015
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