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Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging

The number of newly formed neurons declines rapidly during aging, and this decrease in neurogenesis is associated with decreased function of neural stem/progenitor cells (NPCs). Here, we determined that a WIP1-dependent pathway regulates NPC differentiation and contributes to the age-associated decl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhu, Yunhua, Demidov, Oleg N., Goh, Amanda M., Virshup, David M., Lane, David P., Bulavin, Dmitry V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071391/
https://ncbi.nlm.nih.gov/pubmed/24911145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73015
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