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GroEL/ES Chaperonin Modulates the Mechanism and Accelerates the Rate of TIM-Barrel Domain Folding
The GroEL/ES chaperonin system functions as a protein folding cage. Many obligate substrates of GroEL share the (βα)(8) TIM-barrel fold, but how the chaperonin promotes folding of these proteins is not known. Here we analyzed the folding of DapA at peptide resolution using hydrogen/deuterium exchang...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4071350/ https://ncbi.nlm.nih.gov/pubmed/24813614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.038 |
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