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Conformational specificity of the chaperonin GroEL for the compact folding intermediates of alpha-lactalbumin.

The chaperonin GroEL binds unfolded polypeptides, preventing aggregation, and then mediates their folding in an ATP-dependent process. To understand the structural features in non-native polypeptides recognized by GroEL, we have used alpha-lactalbumin (alpha LA) as a model substrate. alpha LA (14.2...

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Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Hayer-Hartl, M K, Ewbank, J J, Creighton, T E, Hartl, F U
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 1994
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395211/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7913682/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06618.x
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