GroEL/ES Chaperonin Modulates the Mechanism and Accelerates the Rate of TIM-Barrel Domain Folding

The GroEL/ES chaperonin system functions as a protein folding cage. Many obligate substrates of GroEL share the (βα)(8) TIM-barrel fold, but how the chaperonin promotes folding of these proteins is not known. Here we analyzed the folding of DapA at peptide resolution using hydrogen/deuterium exchang...

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Detaylı Bibliyografya
Asıl Yazarlar: Georgescauld, Florian, Popova, Kristina, Gupta, Amit J., Bracher, Andreas, Engen, John R., Hayer-Hartl, Manajit, Hartl, F. Ulrich
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071350/
https://ncbi.nlm.nih.gov/pubmed/24813614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.038
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