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Simplification of Complex Physiologically Based Pharmacokinetic Models of Monoclonal Antibodies

Monoclonal antibodies (mAbs) exhibit biexponential profiles in plasma that are commonly described with a standard two-compartment model with elimination from the central compartment. These models adequately describe mAb plasma PK. However, these models ignore elimination from the peripheral compartm...

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Sonraí Bibleagrafaíochta
Main Authors: Elmeliegy, Mohamed, Lowe, Philip, Krzyzanski, Wojciech
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer US 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070266/
https://ncbi.nlm.nih.gov/pubmed/24871341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9591-x
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