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Simplification of Complex Physiologically Based Pharmacokinetic Models of Monoclonal Antibodies
Monoclonal antibodies (mAbs) exhibit biexponential profiles in plasma that are commonly described with a standard two-compartment model with elimination from the central compartment. These models adequately describe mAb plasma PK. However, these models ignore elimination from the peripheral compartm...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Springer US
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4070266/ https://ncbi.nlm.nih.gov/pubmed/24871341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9591-x |
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