Replica Exchange Molecular Dynamics Simulations Provide Insight into Substrate Recognition by Small Heat Shock Proteins

The small heat shock proteins (sHSPs) are a virtually ubiquitous and diverse group of molecular chaperones that can bind and protect unfolding proteins from irreversible aggregation. It has been suggested that intrinsic disorder of the N-terminal arm (NTA) of sHSPs is important for substrate recogni...

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Bibliografische gegevens
Hoofdauteurs: Patel, Sunita, Vierling, Elizabeth, Tama, Florence
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Biophysical Society 2014
Onderwerpen:
Proteins and Nucleic Acids
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070073/
https://ncbi.nlm.nih.gov/pubmed/24940782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.04.048
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