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Cryo-Cooling Effect on DHFR Crystal Studied by Replica-Exchange Molecular Dynamics Simulations

Cryo-cooling is routinely performed before x-ray diffraction image collection to reduce the damage to crystals due to ionizing radiation. It has been suggested that although backbone structures are usually very similar between room temperature and cryo-temperature, cryo-cooling may hamper biological...

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Publicat a:Biophys J
Autors principals: Nagai, Tetsuro, Tama, Florence, Miyashita, Osamu
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369401/
https://ncbi.nlm.nih.gov/pubmed/30638963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.11.3139
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