Origin of Robustness in Generating Drug-Resistant Malaria Parasites

Biological robustness allows mutations to accumulate while maintaining functional phenotypes. Despite its crucial role in evolutionary processes, the mechanistic details of how robustness originates remain elusive. Using an evolutionary trajectory analysis approach, we demonstrate how robustness evo...

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Detalhes bibliográficos
Main Authors: Kümpornsin, Krittikorn, Modchang, Charin, Heinberg, Adina, Ekland, Eric H., Jirawatcharadech, Piyaporn, Chobson, Pornpimol, Suwanakitti, Nattida, Chaotheing, Sastra, Wilairat, Prapon, Deitsch, Kirk W., Kamchonwongpaisan, Sumalee, Fidock, David A., Kirkman, Laura A., Yuthavong, Yongyuth, Chookajorn, Thanat
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069624/
https://ncbi.nlm.nih.gov/pubmed/24739308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msu140
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