Nuclear MEK1 Sequesters PPARγ and Bisects MEK1/ERK Signaling: A Non-Canonical Pathway of Retinoic Acid Inhibition of Adipocyte Differentiation

Uncontrolled adipogenesis and adipocyte proliferation have been connected to human comorbidities. Retinoic acid (RA) is known to inhibit adipocyte differentiation, however the underlying mechanisms have not been adequately understood. This study reports that RA acting as a ligand to RA receptors (RA...

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Bibliographische Detailangaben
Hauptverfasser: Dave, Sandeep, Nanduri, Ravikanth, Dkhar, Hedwin Kitdorlang, Bhagyaraj, Ella, Rao, Alka, Gupta, Pawan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069188/
https://ncbi.nlm.nih.gov/pubmed/24959884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100862
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