Inter-α-Inhibitor Blocks Epithelial Sodium Channel Activation and Decreases Nasal Potential Differences in ΔF508 Mice

Increased activity of lung epithelial sodium channels (ENaCs) contributes to the pathophysiology of cystic fibrosis (CF) by increasing the rate of epithelial lining fluid reabsorption. Inter-α-inhibitor (IαI), a serum protease inhibitor, may decrease ENaC activity by preventing its cleavage by serin...

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Bibliografische gegevens
Hoofdauteurs: Lazrak, Ahmed, Jurkuvenaite, Asta, Ness, Emily C., Zhang, Shaoyan, Woodworth, Bradford A., Muhlebach, Marianne S., Stober, Vandy P., Lim, Yow-Pin, Garantziotis, Stavros, Matalon, Sadis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Thoracic Society 2014
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068944/
https://ncbi.nlm.nih.gov/pubmed/24303840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0215OC
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