Inter-α-Inhibitor Blocks Epithelial Sodium Channel Activation and Decreases Nasal Potential Differences in ΔF508 Mice

Increased activity of lung epithelial sodium channels (ENaCs) contributes to the pathophysiology of cystic fibrosis (CF) by increasing the rate of epithelial lining fluid reabsorption. Inter-α-inhibitor (IαI), a serum protease inhibitor, may decrease ENaC activity by preventing its cleavage by serin...

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Detalhes bibliográficos
Main Authors: Lazrak, Ahmed, Jurkuvenaite, Asta, Ness, Emily C., Zhang, Shaoyan, Woodworth, Bradford A., Muhlebach, Marianne S., Stober, Vandy P., Lim, Yow-Pin, Garantziotis, Stavros, Matalon, Sadis
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068944/
https://ncbi.nlm.nih.gov/pubmed/24303840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0215OC
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