Cystic Fibrosis Transmembrane Conductance Regulator Activation by Roflumilast Contributes to Therapeutic Benefit in Chronic Bronchitis

Cigarette smoking causes acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction and is associated with delayed mucociliary clearance and chronic bronchitis. Roflumilast is a clinically approved phosphodiesterase 4 inhibitor that improves lung function in patients with chroni...

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Bibliographische Detailangaben
Hauptverfasser: Lambert, James A., Raju, S. Vamsee, Tang, Li Ping, McNicholas, Carmel M., Li, Yao, Courville, Clifford A., Farris, Roopan F., Coricor, George E., Smoot, Lisa H., Mazur, Marina M., Dransfield, Mark T., Bolger, Graeme B., Rowe, Steven M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2014
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068936/
https://ncbi.nlm.nih.gov/pubmed/24106801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0228OC
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