Cystic Fibrosis Transmembrane Conductance Regulator Activation by Roflumilast Contributes to Therapeutic Benefit in Chronic Bronchitis

Cigarette smoking causes acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction and is associated with delayed mucociliary clearance and chronic bronchitis. Roflumilast is a clinically approved phosphodiesterase 4 inhibitor that improves lung function in patients with chroni...

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Detalhes bibliográficos
Main Authors: Lambert, James A., Raju, S. Vamsee, Tang, Li Ping, McNicholas, Carmel M., Li, Yao, Courville, Clifford A., Farris, Roopan F., Coricor, George E., Smoot, Lisa H., Mazur, Marina M., Dransfield, Mark T., Bolger, Graeme B., Rowe, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068936/
https://ncbi.nlm.nih.gov/pubmed/24106801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0228OC
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