Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in the Lower Airways in COPD

BACKGROUND: Cigarette smoke and smoking-induced inflammation decrease cystic fibrosis transmembrane conductance regulator (CFTR) activity and mucociliary transport in the nasal airway and cultured bronchial epithelial cells. This raises the possibility that lower airway CFTR dysfunction may contribu...

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Main Authors: Dransfield, Mark T., Wilhelm, Andrew M., Flanagan, Brian, Courville, Clifford, Tidwell, Sherry L., Raju, S. Vamsee, Gaggar, Amit, Steele, Chad, Tang, Li Ping, Liu, Bo, Rowe, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado: American College of Chest Physicians 2013
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734887/
https://ncbi.nlm.nih.gov/pubmed/23538783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1378/chest.13-0274
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