Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in the Lower Airways in COPD

BACKGROUND: Cigarette smoke and smoking-induced inflammation decrease cystic fibrosis transmembrane conductance regulator (CFTR) activity and mucociliary transport in the nasal airway and cultured bronchial epithelial cells. This raises the possibility that lower airway CFTR dysfunction may contribu...

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Bibliografiske detaljer
Main Authors: Dransfield, Mark T., Wilhelm, Andrew M., Flanagan, Brian, Courville, Clifford, Tidwell, Sherry L., Raju, S. Vamsee, Gaggar, Amit, Steele, Chad, Tang, Li Ping, Liu, Bo, Rowe, Steven M.
Format: Artigo
Sprog:Inglês
Udgivet: American College of Chest Physicians 2013
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734887/
https://ncbi.nlm.nih.gov/pubmed/23538783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1378/chest.13-0274
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