Endothelin-1 Induces a Glycolytic Switch in Pulmonary Arterial Endothelial Cells via the Mitochondrial Translocation of Endothelial Nitric Oxide Synthase

Recent studies have indicated that, during the development of pulmonary hypertension (PH), there is a switch from oxidative phosphorylation to glycolysis in the pulmonary endothelium. However, the mechanisms underlying this phenomenon have not been elucidated. Endothelin (ET)-1, an endothelial-deriv...

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Détails bibliographiques
Auteurs principaux: Sun, Xutong, Kumar, Sanjiv, Sharma, Shruti, Aggarwal, Saurabh, Lu, Qing, Gross, Christine, Rafikova, Olga, Lee, Sung Gon, Dasarathy, Sridevi, Hou, Yali, Meadows, Mary Louise, Han, Weihong, Su, Yunchao, Fineman, Jeffrey R., Black, Stephen M.
Format: Artigo
Langue:Inglês
Publié: American Thoracic Society 2014
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068912/
https://ncbi.nlm.nih.gov/pubmed/24392990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0187OC
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