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The Emerging Mutational Landscape of G-proteins and G-protein Coupled Receptors in Cancer
Aberrant expression and activity of G proteins and G protein coupled receptors (GPCRs) are frequently associated with tumorigenesis. Deep sequencing studies show that 4.2% of tumors carry activating mutations in GNAS (encoding Gα(s)), and that oncogenic activating mutants in genes encoding Gα(q) fam...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4068741/ https://ncbi.nlm.nih.gov/pubmed/23640210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc3521 |
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