Structural and Biochemical Basis for Ubiquitin Ligase Recruitment by Arrestin-related Domain-containing Protein-3 (ARRDC3)

After protracted stimulation, the β2-adrenergic receptor and many other G-protein-coupled receptors are ubiquitinated and down-regulated. Arrestin-related domain-containing protein-3 (ARRDC3) has been proposed to recruit the ubiquitin ligase Nedd4 to the β2-adrenergic receptor. ARRDC3 contains two P...

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Bibliografiske detaljer
Main Authors: Qi, Shiqian, O'Hayre, Morgan, Gutkind, J. Silvio, Hurley, James H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931036/
https://ncbi.nlm.nih.gov/pubmed/24379409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527473
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