Pharmacokinetic Comparison To Determine the Mechanisms Underlying the Differential Efficacies of Cationic Diamidines against First- and Second-Stage Human African Trypanosomiasis

Human African trypanosomiasis (HAT), a neglected tropical disease, is fatal without treatment. Pentamidine, a cationic diamidine, has been used to treat first-stage (hemolymphatic) HAT since the 1940s, but it is ineffective against second-stage (meningoencephalitic, or central nervous system [CNS])...

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Detalhes bibliográficos
Main Authors: Yang, Sihyung, Wenzler, Tanja, Miller, Patrik N., Wu, Huali, Boykin, David W., Brun, Reto, Wang, Michael Zhuo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068519/
https://ncbi.nlm.nih.gov/pubmed/24798280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02605-14
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