Nonnucleoside Inhibitors of Norovirus RNA Polymerase: Scaffolds for Rational Drug Design

Norovirus (NoV) is the leading cause of acute gastroenteritis worldwide, causing over 200,000 deaths a year. NoV is nonenveloped, with a single-stranded RNA genome, and is primarily transmitted person to person. The viral RNA-dependent RNA polymerase (RdRp) is critical for the production of genomic...

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Main Authors: Eltahla, Auda A., Lim, Kun Lee, Eden, John-Sebastian, Kelly, Andrew G., Mackenzie, Jason M., White, Peter A.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2014
主題:
Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068436/
https://ncbi.nlm.nih.gov/pubmed/24637690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02799-13
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