Characterization of the Population Pharmacokinetics of Ampicillin in Neonates Using an Opportunistic Study Design

Although ampicillin is the most commonly used drug in neonates, developmental pharmacokinetic (PK) data to guide dosing are lacking. Ampicillin is primarily renally eliminated, and developmental changes are expected to influence PK. We conducted an open-label, multicenter, opportunistic, prospective...

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Detalhes bibliográficos
Main Authors: Tremoulet, Adriana, Le, Jennifer, Poindexter, Brenda, Sullivan, Janice E., Laughon, Matthew, Delmore, Paula, Salgado, Andrea, Ian-U Chong, Sandy, Melloni, Chiara, Gao, Jamie, Benjamin, Daniel K., Capparelli, Edmund V., Cohen-Wolkowiez, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068432/
https://ncbi.nlm.nih.gov/pubmed/24614374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02374-13
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