Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates

BACKGROUND: Dried blood spot (DBS) is a practical sampling strategy for pharmacokinetic studies in neonates. The utility of DBS to determine the population pharmacokinetics (pop-PK) of ampicillin, as well as accuracy versus plasma samples, was evaluated. METHODS: An open-label, multicenter, opportun...

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Detalhes bibliográficos
Publicado no:Ther Drug Monit
Main Authors: Le, Jennifer, Poindexter, Brenda, Sullivan, Janice E., Laughon, Matthew, Delmore, Paula, Blackford, Martha, Yogev, Ram, James, Laura P., Melloni, Chiara, Harper, Barrie, Mitchell, Jeff, Benjamin, Daniel K., Boakye-Agyeman, Felix, Cohen-Wolkowiez, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764797/
https://ncbi.nlm.nih.gov/pubmed/29271816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0000000000000466
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