Randomized, Placebo-Controlled, Single-Ascending-Dose Study of BMS-791325, a Hepatitis C Virus (HCV) NS5B Polymerase Inhibitor, in HCV Genotype 1 Infection

BMS-791325 is a nonnucleoside inhibitor of hepatitis C virus (HCV) NS5B polymerase with low-nanomolar potency against genotypes 1a (50% effective concentration [EC(50)], 3 nM) and 1b (EC(50), 7 nM) in vitro. BMS-791325 safety, pharmacokinetics, and antiviral activity were evaluated in a double-blind...

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Autori principali: Sims, Karen D., Lemm, Julie, Eley, Timothy, Liu, Menping, Berglind, Anna, Sherman, Diane, Lawitz, Eric, Vutikullird, Apinya B., Tebas, Pablo, Gao, Min, Pasquinelli, Claudio, Grasela, Dennis M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068419/
https://ncbi.nlm.nih.gov/pubmed/24733462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02579-13
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