Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins

The regulated turnover of endoplasmic reticulum (ER)–resident membrane proteins requires their extraction from the membrane lipid bilayer and subsequent proteasome-mediated degradation. Cleavage within the transmembrane domain provides an attractive mechanism to facilitate protein dislocation but ha...

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Main Authors: Boname, Jessica M., Bloor, Stuart, Wandel, Michal P., Nathan, James A., Antrobus, Robin, Dingwell, Kevin S., Thurston, Teresa L., Smith, Duncan L., Smith, James C., Randow, Felix, Lehner, Paul J.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068138/
https://ncbi.nlm.nih.gov/pubmed/24958774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201312009
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