LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status

Missense mutations in the Leucine-Rich Repeat protein Kinase 2 (LRRK2) gene are the most common genetic predisposition to develop Parkinson’s disease (PD) (Farrer et al., 2005; Skipper et al., 2005; Di Fonzo et al., 2006; Healy et al., 2008; Paisan-Ruiz et al., 2008; Lesage et al., 2010). LRRK2 is a...

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Bibliografiska uppgifter
Huvudupphovsmän: Reynolds, April, Doggett, Elizabeth A., Riddle, Steve M., Lebakken, Connie S., Nichols, R. Jeremy
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2014
Ämnen:
Neuroscience
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068021/
https://ncbi.nlm.nih.gov/pubmed/25009464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2014.00054
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