From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects

The superordinate principles governing the transcriptome response of differentiating cells exposed to drugs are still unclear. Often, it is assumed that toxicogenomics data reflect the immediate mode of action (MoA) of drugs. Alternatively, transcriptome changes could describe altered differentiatio...

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Bibliographic Details
Main Authors: Balmer, Nina V., Klima, Stefanie, Rempel, Eugen, Ivanova, Violeta N., Kolde, Raivo, Weng, Matthias K., Meganathan, Kesavan, Henry, Margit, Sachinidis, Agapios, Berthold, Michael R., Hengstler, Jan G., Rahnenführer, Jörg, Waldmann, Tanja, Leist, Marcel
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2014
Subjects:
Reproductive Toxicology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067541/
https://ncbi.nlm.nih.gov/pubmed/24935251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-014-1279-6
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