sgRNAcas9: A Software Package for Designing CRISPR sgRNA and Evaluating Potential Off-Target Cleavage Sites

Although the CRISPR/Cas9/sgRNA system efficiently cleaves intracellular DNA at desired target sites, major concerns remain on potential “off-target” cleavage that may occur throughout the whole genome. In order to improve CRISPR-Cas9 specificity for targeted genome editing and transcriptional contro...

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Bibliographic Details
Main Authors: Xie, Shengsong, Shen, Bin, Zhang, Chaobao, Huang, Xingxu, Zhang, Yonglian
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067335/
https://ncbi.nlm.nih.gov/pubmed/24956386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100448
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