Effector-mediated eradication of precursor B acute lymphoblastic leukemia with a novel Fc engineered monoclonal antibody targeting the BAFF-R

B-cell activating factor receptor (BAFF-R) is expressed on precursor B acute lymphoblastic leukemia ALL (pre-B ALL) cells but not on their pre-B normal counterparts. Thus, selective killing of ALL cells is possible by targeting this receptor. Here we have further examined therapeutic targeting of pr...

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Autores principales: Parameswaran, Reshmi, Lim, Min, Fei, Fei, Abdel-Azim, Hisham, Arutyunyan, Anna, Schiffer, Isabelle, McLaughlin, Margaret E., Gram, Hermann, Huet, Heather, Groffen, John, Heisterkamp, Nora
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067324/
https://ncbi.nlm.nih.gov/pubmed/24825858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-1023
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