Key Role of the Endothelial TGF-β/ALK1/Endoglin Signaling Pathway in Humans and Rodents Pulmonary Hypertension

Mutations affecting transforming growth factor-beta (TGF-β) superfamily receptors, activin receptor-like kinase (ALK)-1, and endoglin (ENG) occur in patients with pulmonary arterial hypertension (PAH). To determine whether the TGF-β/ALK1/ENG pathway was involved in PAH, we investigated pulmonary TGF...

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Main Authors: Gore, Benoît, Izikki, Mohamed, Mercier, Olaf, Dewachter, Laurence, Fadel, Elie, Humbert, Marc, Dartevelle, Philippe, Simonneau, Gerald, Naeije, Robert, Lebrin, Franck, Eddahibi, Saadia
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067299/
https://ncbi.nlm.nih.gov/pubmed/24956016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100310
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